Endocrinology and Metabolism

Yong Seong Kim (Kim YS)

14 Articles

Obesity and Metabolism
Metformin-Associated Lactic Acidosis: Predisposing Factors and Outcome: Min Ju Kim, Ju Young Han, Jun Young Shin, Shin Il Kim, Jeong Min Lee, Seongbin Hong, So Hun Kim, Moon Suk Nam, Yong Seong Kim; Endocrinol Metab. 2015;30(1):78-83. Published online March 27, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.1.78

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Background

Metformin is considered the first choice oral treatment for type 2 diabetes patients in the absence of contraindications. Rarely, life-threatening complications associated with metformin treatment are seen in some patients with underlying diseases. The aim of this study was to further investigate the clinical profiles and risk factors for metformin-associated lactic acidosis (MALA) and the treatment modalities according to survival.

Methods

To identify MALA, we performed a retrospective study in seven diabetic patients who were taking metformin and had been diagnosed with lactic acidosis at Inha University Hospital between 1995 and 2012. For each patient, we recorded the age, sex, daily metformin dosage, laboratory test results, admission diagnosis, and risk factors. Also, concurrent conditions, treatment modalities, and outcomes were evaluated.

Results

Six patients had risk factors for lactic acidosis before admission. All patients had renal impairment on admission as a precipitating risk factor. Five patients survived and two patients died despite early renal replacement therapy. Older patients tended to have a poorer prognosis.

Conclusion

Renal function must be monitored in elderly type 2 diabetes mellitus patients with underlying diseases and conditions causing renal impairment who begin metformin treatment. Accurate recognition of MALA and initiation of renal replacement are essential for treatment.

Citations

Citations to this article as recorded by

An Analysis of Clinical Outcomes of Exploratory Pediatric Metformin Ingestions Reported to the Texas Poison Center Network From 2011 to 2021
Shawn M. Varney, Sarah Watkins, Haylea Stuteville, Mark L. Winter, Han Tony Gao, Thomas G. Martin, Ryan P. Morrissey, Wayne R. Snodgrass, Brett A. Roth
Hospital Pharmacy.2024;[Epub] CrossRef
Metformin Treatment Reduces the Incidence of Rheumatoid Arthritis: A Two-Sample Mendelian Randomized Study
Jialin Liang, Yuanqing Cai, Jianan Zhang, Zhaopu Jing, Leifeng Lv, Guangyang Zhang, Rupeng Zhang, Ruiyu Liu, Kai Nan, Xiaoqian Dang
Journal of Clinical Medicine.2023; 12(7): 2461. CrossRef
PLGA-based microspheres loaded with metformin hydrochloride: Modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Priyanka Chauhan, Himanshu Paliwal, Chetan Singh Chauhan, Ankit Paliwal
Annales Pharmaceutiques Françaises.2023; 81(6): 997. CrossRef
Metformin-associated lactic acidosis: underlying multiple myeloma
Clara GOMES, Ana FERREIRA, Neuza SOARES, Vanessa CHAVES, Luís LEMOS, Sofia TAVARES, Marta COUTO
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef
Metformin-associated lactic acidosis and factors associated with 30-day mortality
Kanin Thammavaranucupt, Boonchan Phonyangnok, Watanyu Parapiboon, Laddaporn Wongluechai, Watthikorn Pichitporn, Jirut Sumrittivanicha, Somnuek Sungkanuparph, Arkom Nongnuch, Kulapong Jayanama, Donovan Anthony McGrowder
PLOS ONE.2022; 17(8): e0273678. CrossRef
Metformin Associated Lactic Acidosis in Clinical Practice – A Case Series
Philipp Schädle, Otto Tschritter, Monika Kellerer
Experimental and Clinical Endocrinology & Diabetes.2021; 129(11): 842. CrossRef
Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
Qi Yu, Jia-Jia Zhu, Wen-Xian Liu
BMC Cardiovascular Disorders.2020;[Epub] CrossRef
Metformin: current clinical applications in nondiabetic patients with cancer
Kailin Chen, Yajun Li, Zhen Guo, Yong Zeng, Wei Zhang, Hui Wang
Aging.2020; 12(4): 3993. CrossRef
Specifics of diabetes in old age
Markéta Kubíčková
Interní medicína pro praxi.2019; 21(4): 223. CrossRef
The Association between Metformin Therapy and Lactic Acidosis
Isabelle H. S. Kuan, Ruth L. Savage, Stephen B. Duffull, Robert J. Walker, Daniel F. B. Wright
Drug Safety.2019; 42(12): 1449. CrossRef
Metformin overdose: A serious iatrogenic complication—Western France Poison Control Centre Data Analysis
Alexandre Stevens, Jean‐François Hamel, Ali Toure, Samy Hadjadj, David Boels
Basic & Clinical Pharmacology & Toxicology.2019; 125(5): 466. CrossRef
Risk of Metformin-Associated Lactic Acidosis (MALA) in Patients After Gastric Bypass Surgery
Laura N. Deden, Edo O. Aarts, Stephanie C. W. Aelfers, Marcel M. G. J. van Borren, Ignace M. C. Janssen, Frits J. Berends, Hans de Boer
Obesity Surgery.2018; 28(4): 1080. CrossRef
Metformin-related lactic acidosis: Case report
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Colombian Journal of Anesthesiology.2017; 45(4): 353. CrossRef
Metformin-related lactic acidosis: Case report☆
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Colombian Journal of Anesthesiology.2017; 45(4): 353. CrossRef
Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes
Eun Young Lee, Sena Hwang, Yong-ho Lee, Seo Hee Lee, Young Mi Lee, Hua Pyong Kang, Eugene Han, Woonhyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee
Yonsei Medical Journal.2017; 58(2): 312. CrossRef
Hypoglycemia and severe lactic acidosis in a dog following metformin exposure
Nicole Barrella, Beth Eisenberg, Stephanie Nicole Simpson
Clinical Case Reports.2017; 5(12): 2097. CrossRef
Acidosis láctica por metformina: reporte de caso
Jesús Salvador Sánchez-Díaz, Enrique Monares-Zepeda, Enrique Antonio Martínez-Rodríguez, Jorge Samuel Cortés-Román, Oscar Torres-Aguilar, Karla Gabriela Peniche-Moguel, Susana Patricia Díaz-Gutiérrez, Eusebio Pin-Gutiérrez, Gerardo Rivera-Solís, Rosalba C
Revista Colombiana de Anestesiología.2017; 45(4): 353. CrossRef
Towards natural mimetics of metformin and rapamycin
Alexander Aliper, Leslie Jellen, Franco Cortese, Artem Artemov, Darla Karpinsky-Semper, Alexey Moskalev, Andrew G. Swick, Alex Zhavoronkov
Aging.2017; 9(11): 2245. CrossRef
Metformin-Associated Lactic Acidosis
Martin R. Hevesy
Advanced Emergency Nursing Journal.2017; 39(1): 26. CrossRef
Metformin associated lactic acidosis (MALA): clinical profiling and management
Alessandra Moioli, Barbara Maresca, Andrea Manzione, Antonello Maria Napoletano, Daniela Coclite, Nicola Pirozzi, Giorgio Punzo, Paolo Menè
Journal of Nephrology.2016; 29(6): 783. CrossRef
Risk assessment and management of post-transplant diabetes mellitus
Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
Metabolism.2016; 65(10): 1559. CrossRef
Temporal trends in the use of antidiabetic medicines: a nationwide 9-year study in older people living in New Zealand
Prasad S. Nishtala, Mohammed Saji Salahudeen
Therapeutic Advances in Drug Safety.2016; 7(5): 184. CrossRef
Metformin-associated lactic acidosis: Current perspectives on causes and risk
Ralph DeFronzo, G. Alexander Fleming, Kim Chen, Thomas A. Bicsak
Metabolism.2016; 65(2): 20. CrossRef
Lactic acidosis and the relationship with metformin usage
Weiyi Huang, Ronald L. Castelino, Gregory M. Peterson
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Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states
Hye Suk Kang, Ho-Chan Cho, Jae-Ho Lee, Goo Taeg Oh, Seung-Hoi Koo, Byung-Hyun Park, In-Kyu Lee, Hueng-Sik Choi, Dae-Kyu Song, Seung-Soon Im
Scientific Reports.2016;[Epub] CrossRef
Metformin-associated lactic acidosis: time to let it go?
Chantal Mathieu
Journal of Diabetes and its Complications.2015; 29(8): 974. CrossRef
Metformin: risk-benefit profile with a focus on cancer
Nicoletta Provinciali, Matteo Lazzeroni, Massimiliano Cazzaniga, Franco Gorlero, Barbara K Dunn, Andrea DeCensi
Expert Opinion on Drug Safety.2015; 14(10): 1573. CrossRef

A Case of Spontaneous Rupture of Adrenal Pheochromocytoma.: Eun Joo Kim, Mie Jin Lim, Byoung Wook Bang, Hyun Joo Park, Seong Bin Hong, Moon Suk Nam, Yong Seong Kim, Suk Jin Choi; J Korean Endocr Soc. 2006;21(5):424-427. Published online October 1, 2006; DOI: https://doi.org/10.3803/jkes.2006.21.5.424

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Abstract PDF

Although the spontaneous rupture of a pheochromocytoma is rare, it can be fatal if not promptly diagnosed. Hemorrhagic necrosis of the tumor will require an emergency operation, as this causes intraperitoneal hemorrhaging. Excessive vasoconstriction, tachycardia and labile blood pressure are the signs of a ruptured pheochromocytoma. The standard diagnostic tool of such a condition is an abdominal computed tomographic scan. Although the exact mechanism of the rupture is still unknown, a hemorrhage inside the tumor or a high intra-cortical pressure, due to rapid growth of the tumor, is known to play a major role in the pathogenesis. Herein is reported the case of a 53-year old male patient with a pheochromocytoma and an acute abdomen. The CT scan showed a left adrenal gland mass, with a hemorrhage in the left perirenal space. The patient underwent an emergency adrenalectomy, with the final histopathological diagnosis being that of a pheochromocytoma. Prompt recognition and early surgical intervention can improve outcome.

Citations

Citations to this article as recorded by

Ruptured functioning adrenal tumour, atypical presentation with renal colic and hypertension
Amr Elmoheen, Mohamed Yousry, Ahmed Elmesery, Khalid Bashir
BMJ Case Reports.2020; 13(12): e236050. CrossRef
Spontaneous ruptured pheochromocytoma: an unusual case report and literature review
Ye Seob Jee
Annals of Surgical Treatment and Research.2017; 93(3): 170. CrossRef

A Case of Bilateral Macronodular Adrenocortical Hyperplasia Accompanied by Hyperresponsiveness to Vasopressin.: Deok In Kim, Seung Hee Lee, Eun A Kim, Hwi La Park, Gyeong Ug Lee, Seong Bin Hong, Moon Suk Nam, Seok Hwan Shin, Yong Seong Kim; J Korean Endocr Soc. 2005;20(4):390-394. Published online August 1, 2005; DOI: https://doi.org/10.3803/jkes.2005.20.4.390

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Abstract PDF: Cushing's syndrome associated with nodular adrenal hyperplasia glands is divided into 4 main categories: adrenal adenoma, adrenal carcinoma, primary pigmented nodular adrenal dysplasia and macronodular adrenal hyperplasia(MAH). The mechanism of bilateral MAH, when ACTH is suppressed, was previously unknown, and referred to as being "autonomous". Recently, several reports have shown MAH to be under the control of ectopic or eutopic membrane hormone. Here, a case of Cushing's syndrome, caused by bilateral MAH, is reported. A 62-year-old woman presented with Cushingoid features, hypertension and diabetes mellitus. In her case, abnormal adrenal stimulation of cortisol secretion in response to exogenous vasopression stimulation was shown. Her urine free cortisol was 726.0microgram/dL, which was not suppressed after administration of high-dose dexamethasone. Her plasma cortisol level was elevated, but without circadian rhythm. ACTH was undetectable. An abdomen CT scan demonstrated bilaterally enlarged multinodular adrenal glands. A Sella MRI revealed no alteration of the pituitary gland. The patient underwent a laparoscopic bilateral adrenalectomy. Histological examination revealed bilateral macronodular hyperplasia. After having recovered, the patient showed progressive regression of the Cushingoid status.

A Case of Isolated Familial Somatotropinoma.: Hwi Ra Park, Eun A Kim, Mei Hua Jiang, Chang Soo Jang, Kyoung Wook Lee, Seong Bin Hong, Eun Young Kim, Myung Kwan Lim, Moon Suk Nam, Yong Seong Kim; J Korean Endocr Soc. 2004;19(4):398-405. Published online August 1, 2004

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Abstract PDF: The familial occurrence of a pituitary adenoma associated with multiple endocrine neoplasia (MEN) type 1 or Carney complex is a well-recognized entity. However, an isolated familial somatotropinoma is a rare inherited disease, which is characterized by clustering of a somatotrophic adenoma and acromegaly or gigantism in a family, but without other manifestations of MEN type 1, with only 68 cases, in 28 families, described in the literature. The mode of inheritance is autosomal dominant, with incomplete penetration, but the genetic background of these pituitary adenomas remains unknown. A family exists where both the father and son were affected. Endocrinological investigations confirmed hypersecretion of GH and IGF-1, and the pituitary adenomas were identified by magnetic resonance image in both cases. There was no symptom of MEN type 1 or other form of endocrine dysfunction. Herein is reported a case of an isolated familial somatotropinoma in Korea, with a review of the literature

Low Dose and High Dose ACTH Test in Adrenal Insufficiency.: Yong Seong Kim; J Korean Endocr Soc. 2004;19(1):19-23. Published online February 1, 2004

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Abstract PDF: No abstract available.

Rhabdomyolysis Associated with Hyponatremia.: Kyoung Wook Lee, Seong Bin Hong, Seung Baik Han, Bon Ju Jeong, Hwi Ra Park, Eun Sil Kim, Dong Hyo Hyun, Moon Suk Nam, Yong Seong Kim; J Korean Endocr Soc. 2003;18(3):306-310. Published online June 1, 2003

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Abstract PDF: Hyponatremia is a frequent condition of body fluid and electrolyte imbalance encountered in clinical practice. However, rhabdomyolysis has rarely been reported in association with hyponatremia. We experienced a 56-year-old woman who had developed symptomatic hyponatremia after prolonged nausea and subsequent rhabdomyolysis. Hyponatremia was probably mediated by hypersecretion of antidiuretic hormones.The woman had developed severe hypotonic hyponatremia with an alternation in mental status after suffering from severe nausea and vomiting for x months/years. She recovered with intensive supportive therapy, including hypertonic saline administration. One day after hospitalization, she complained of thigh pains; furthermore her serum creatine phosphokinase level had increased. She was treated with alkaline diuresis. Renal failure or compartment syndrome did not complicate the clinical course. The patient was discharged and returned to her normal daily activities. The possibility of rhabdomyolysis should be considered in patients with acute hyponatremia who have developed muscle pain.

Non-alcoholic Fatty Liver Disease and Metabolic Syndrome.: Yong Seong Kim; J Korean Endocr Soc. 2002;17(4):460-464. Published online August 1, 2002

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Abstract PDF: No abstract available.

Histomorphometry of Osteogenesis Imperfecta I.: Seong Bin Hong, Suk Myun Ko, Yong Koo Park, Young Joo Park, Yoon Juo Oh, Young Wan Kim, Sung Ki Kim, Moon Suk Nam, Yong Seong Kim; J Korean Endocr Soc. 2002;17(1):117-123. Published online February 1, 2002

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Abstract PDF: Osteoporosis imperfecta (OI) is a genetic disorder characterized by fragility of bone, deafness, blue sclerae; and laxity of joints. Four types of OI are distinguished by clinical findings. Although mutations affecting collagen I are responsible for the disease in the most patients, the mechanism by which the genetic defects cause abnormal bone development has not been well established. Therefore we evaluated static and dynamic bone histomorphometry of type I OI in the case study of a 15 year old boy with OI who had blue sclerae, a history of frequent fracture and a familial history of blue sclerae. Biopsy of the ilium showed loss of connection between the cortical bone and trabecular bones. The Harversian system in the cortical bone was poorly developed. In the trabecular bones, the lamellar pattern was poorly developed. Mineral apposition rate of the cortical bone was 1.0 m/day and of the trabecular bone was 0.79 m/day. Thus OI might be regard as a disease whereby abnormal collagen synthesis interferes with bone strength by multiple mechanisms.

A Case of Pancytopenia Caused by Sheehan's Syndorme Improved with Hormone Replacement Therapy.: Sung Ki Kim, Yoon Ju Oh, Park Young Joo, Young Whan Kim, Seong Bin Hong, Mi Rim Kim, Moon Suk Nam, Yong Seong Kim; J Korean Endocr Soc. 2000;15(4-5):595-599. Published online January 1, 2001

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Abstract PDF: Postpartum ischemic necrosis of the pituitary gland, known as Sheehan's syndrome, is well- established clinical entity. In anterior pituitary insufficiency, there is very often a normochromic or hypochromic anemia but pancytopenia secondary to the hypopituitarism is less common. We report a case of pancytopenia due to complete aplasia of the bone marrow associated with Sheehan's syndrome, in which hormone replacement therapy alone produced full hematological recovery.

A Case of Delayed Puberty due to Hypoplasia of Anterior Pituitary Gland with Pituitary Stalk Agenesis and Ectopic Neurohypophysis.: Seung Yong Shin, Jin Young Kim, Seung Jae Yoon, Sung Ki Kim, Seong Bin Hong, Yeo Joo Kim, Moon Suk Nam, Mi Rim Kim, Yong Seong Kim; J Korean Endocr Soc. 1999;14(3):578-586. Published online January 1, 2001

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Abstract PDF: Hypopituitarism is not a common cause of delayed puberty, however it should always be considered, especially if there are such signs as severe dwarfism, dollish face, truncal obesity, small hands and feet, and microgenitalia. Either congenital or acquired, hypopituitarism can be resulted from hypothalamic and hypophyseal lesions. The clinical feature can be diverse depending on age of the patients, rate of progression, degree of hormone deficiency and characteristics of the lesion. The recent high interest in delayed puberty and the improved detection of hypothalamic hypophyseal lesions using combined pituitary fuction stimulation test, brain CT and MRJ, has made the differential diagnosis of hypopituitarism possible as the cause of delayed puberty. MRI has shown hypophyeal hypoplasia accompanied by anterior pituitary hypoplasia and ectopic neurohypophysis in some of the patients with hypopituitasm, and although the anatomical abnormality around the hypophysis in these patients is considered the reason for hypopituitarism, the pathogensis of which has not yet to be known. We, here, report a case of delayed puberty by hypopituitarism due to hypoplasia of anterior pituitary gland, pituitary stalk agenesis and ectopic neurohypophysis with brief review of the litereature.

A Case of Normal Full Term Delivery after Afrenalectomy for Cushing's Syndrome in a Pregnant Patient.: Sung Sik Yang, Yong Seong Kim, Yong Bum Cho, Young Wan Kim, Seong Bin Hong, Yeo Joo Kim, Mi Rim Kim, Moon Suk Nam, Sei Joong Kim, Suk Hwan Shin, Byoung Ick Lee; J Korean Endocr Soc. 1999;14(3):562-567. Published online January 1, 2001

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Abstract PDF: We experienced a case of Cushings syndrome due to adrenal adenoma associated with pregnancy 23th week in a 26 year old female patient. On physical findings, hypertension, moon face, hirsutism, abdominal striae and buffalo hump were noticed. Laboratory findings showed increased serum cortisol, increased 24 hours-urinary cortisol, and decreased plasma ACTH. Abdominal MRI demonstrated 4 cm sized in long diameter, well marginated, and ovoid-shape right adrenal mass. Unilateral total adrenalectomy was performed at the 23th week of pregnancy and the mass it was confirmed to benign adrenal adenoma. Steroid replacement therapy was continued with 7.5 mg prednisolone during remaining pregnancy. At the 38th week of pregnancy, labor was developed and she delivered healthy female weighing 2.5 kg through normal vaginal delivery without complication. Pregnancy rarely occurs in patients with Cushings syndrome. We think she was the first case in Korea who had normal 38th week transvaginal delivery after adrenalectomy in adrenal Cushings syndrome during pregnancy.

A New Model for the Regulartion of Body Weight.: Yong Seong Kim; J Korean Endocr Soc. 1996;11(1):1-6. Published online November 7, 2019

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Abstract PDF: No abstract available.

Effect of cilostazol on diabetic peripheral vascular disease.: Kun Ho Yoon, Je Ho Han, Hyuk Ho Kwon, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Ku Kang, Yong Seong Kim, Hyun Sang Oh, Soon Hyun Shinn; J Korean Endocr Soc. 1993;8(1):78-87. Published online January 1, 2001

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Abstract PDF: No abstract available.

The incidences of autoantibodies after in vivo administration of interferon-gamma.: Myung Shik Lee, Seong Hoe Park, Yong Seong Kim, Noe Kyeong Kim, Think You Kim; J Korean Endocr Soc. 1991;6(3):227-231. Published online January 1, 2001

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Abstract PDF: No abstract available.

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